IN2012DN00968A - - Google Patents
Info
- Publication number
- IN2012DN00968A IN2012DN00968A IN968DEN2012A IN2012DN00968A IN 2012DN00968 A IN2012DN00968 A IN 2012DN00968A IN 968DEN2012 A IN968DEN2012 A IN 968DEN2012A IN 2012DN00968 A IN2012DN00968 A IN 2012DN00968A
- Authority
- IN
- India
- Prior art keywords
- tiotropium bromide
- anhydrous tiotropium
- novel
- compositions
- processes
- Prior art date
Links
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 abstract 3
- 229960000257 tiotropium bromide Drugs 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN968DEN2012 IN2012DN00968A (en]) | 2009-08-07 | 2010-08-06 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1048KO2009 | 2009-08-07 | ||
| PCT/GB2010/051310 WO2011015882A2 (en) | 2009-08-07 | 2010-08-06 | Novel anhydrate |
| IN968DEN2012 IN2012DN00968A (en]) | 2009-08-07 | 2010-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN00968A true IN2012DN00968A (en]) | 2015-04-10 |
Family
ID=42830336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN968DEN2012 IN2012DN00968A (en]) | 2009-08-07 | 2010-08-06 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8697719B2 (en]) |
| EP (1) | EP2462140A2 (en]) |
| JP (2) | JP5822831B2 (en]) |
| CN (1) | CN102639531B (en]) |
| AU (1) | AU2010280497B2 (en]) |
| CA (2) | CA2931876A1 (en]) |
| IN (1) | IN2012DN00968A (en]) |
| NZ (2) | NZ624602A (en]) |
| WO (1) | WO2011015882A2 (en]) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9108962B2 (en) | 2005-12-19 | 2015-08-18 | Sicor, Inc. | Forms of tiotropium bromide and processes for preparation thereof |
| ES2396978T5 (es) | 2005-12-19 | 2015-12-04 | Sicor, Inc. | Forma cristalina novedosa de bromuro de tiotropio y procedimiento para la preparación de la misma |
| AU2010280497B2 (en) | 2009-08-07 | 2015-10-22 | Generics [Uk] Limited | Anhydrate of tiotropium bromide |
| TR201111589A2 (tr) * | 2011-03-03 | 2012-09-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür susuz kristal formu. |
| PT106142B (pt) | 2012-02-10 | 2014-07-18 | Hovione Farmaci Ncia S A | Processo para a preparação de brometo de tiotrópio |
| WO2014042605A1 (en) * | 2012-09-11 | 2014-03-20 | Mahmut Bilgic | New tiotropium bromide crystalline form |
| CN104341413A (zh) * | 2013-07-29 | 2015-02-11 | 天津金耀集团有限公司 | 一种无水噻托溴铵的新晶型 |
| MX2016006377A (es) * | 2013-11-22 | 2016-10-28 | Teva Branded Pharmaceutical Products R&D Inc | Un medicamento inhalable. |
| EP2913332A1 (en) | 2014-02-27 | 2015-09-02 | Euticals S.P.A. | Crystalline form of tiotropium bromide with lactose |
| US10555903B2 (en) * | 2016-10-14 | 2020-02-11 | Glenmark Specialty S.A. | Nebulizable compositions of tiotropium and formoterol |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5610163A (en) | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
| DE3931041C2 (de) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| TR200402579T4 (tr) | 2000-10-12 | 2004-12-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı |
| US6908928B2 (en) | 2000-10-12 | 2005-06-21 | Bi Pharma Kg. | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
| DE10064816A1 (de) | 2000-12-22 | 2002-06-27 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung eines Anticholinergikums |
| US6506900B1 (en) | 2001-01-31 | 2003-01-14 | Boehringer Ingelheim Pharma Ag | Process for preparing a scopine ester intermediate |
| AUPR315301A0 (en) | 2001-02-19 | 2001-03-15 | Silverbrook Research Pty. Ltd. | An Apparatus (ART102) |
| US6608055B2 (en) | 2001-06-22 | 2003-08-19 | Boehringer Ingelheim Pharma Kg | Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition |
| US6610849B2 (en) | 2001-06-28 | 2003-08-26 | Boehringer Ingelheim Pharma Kg | Process for the manufacture of tropenol |
| DE10200943A1 (de) | 2002-01-12 | 2003-07-24 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Scopinestern |
| US6747153B2 (en) | 2002-05-31 | 2004-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Industrial process for preparing tropenol |
| ES2329133T3 (es) | 2003-05-28 | 2009-11-23 | Theravance, Inc. | Compuestos azabicicloalcanicos como antagonistas de receptores de muscarinicos. |
| PE20050996A1 (es) * | 2003-11-03 | 2005-12-20 | Boehringer Ingelheim Int | Nuevo anhidrato cristalino con accion anticolinergica |
| US7968717B2 (en) | 2003-11-03 | 2011-06-28 | Boehringer Ingelhein International Gmbh | Crystalline anhydrate with anticholinergic efficacy |
| CN1271073C (zh) * | 2004-10-26 | 2006-08-23 | 江苏正大天晴药业股份有限公司 | 结晶性抗胆碱能药噻托溴铵晶体 |
| WO2006076222A2 (en) | 2005-01-10 | 2006-07-20 | Glaxo Group Limited | Pharmaceutical formulations |
| BRPI0611091A2 (pt) | 2005-05-02 | 2010-08-03 | Boehringer Ingelheim Int | formas cristalinas de brometo de tiotrópico |
| RU2417224C2 (ru) * | 2005-05-02 | 2011-04-27 | Бёрингер Ингельхайм Интернациональ Гмбх | Новые кристаллические формы тиотропийбромида |
| DE102005035112A1 (de) | 2005-07-27 | 2007-02-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen |
| ES2396978T5 (es) * | 2005-12-19 | 2015-12-04 | Sicor, Inc. | Forma cristalina novedosa de bromuro de tiotropio y procedimiento para la preparación de la misma |
| JP2008530251A (ja) * | 2005-12-19 | 2008-08-07 | シコール インコーポレイティド | 純粋且つ安定な臭化チオトロピウム |
| US20070167480A1 (en) * | 2005-12-19 | 2007-07-19 | Sicor Inc. | Pure and stable tiotropium bromide |
| CN100410254C (zh) * | 2006-03-07 | 2008-08-13 | 南昌弘益科技有限公司 | 噻托溴铵无水物制备方法 |
| US20080051582A1 (en) | 2006-07-10 | 2008-02-28 | Sicor Inc. | Process for the preparation of tiotropium bromide |
| WO2008089852A1 (de) | 2007-01-26 | 2008-07-31 | Boehringer Ingelheim Pharma Gmbh & Co.Kg | Neues verfahren zur herstellung von tiotropiumsalzen |
| DK2120936T3 (da) | 2007-02-21 | 2011-09-26 | Almirall Sa | Nye fremgangsmåder |
| WO2008104955A1 (en) | 2007-02-28 | 2008-09-04 | Ranbaxy Laboratories Limited | Azoniatricyclo [3.3.1.0] nonane derivatives as muscarinic receptor antagonists |
| AU2009203579B2 (en) | 2008-01-10 | 2013-07-25 | Generics [Uk] Limited | Novel process for the preparation of scopine esters |
| WO2011015884A1 (en) | 2009-08-07 | 2011-02-10 | Generics [Uk] Limited | Process to prepare scopine esters |
| WO2011015883A1 (en) | 2009-08-07 | 2011-02-10 | Generics [Uk] Limited | Dichloromethane solvate of tiotropium bromide and its use |
| AU2010280497B2 (en) | 2009-08-07 | 2015-10-22 | Generics [Uk] Limited | Anhydrate of tiotropium bromide |
| WO2011095800A2 (en) | 2010-02-02 | 2011-08-11 | Generics [Uk] Limited | Analytical methods |
-
2010
- 2010-08-06 AU AU2010280497A patent/AU2010280497B2/en not_active Ceased
- 2010-08-06 CA CA2931876A patent/CA2931876A1/en not_active Abandoned
- 2010-08-06 JP JP2012523394A patent/JP5822831B2/ja not_active Expired - Fee Related
- 2010-08-06 NZ NZ624602A patent/NZ624602A/en not_active IP Right Cessation
- 2010-08-06 EP EP10743206.4A patent/EP2462140A2/en not_active Ceased
- 2010-08-06 CA CA2768553A patent/CA2768553C/en not_active Expired - Fee Related
- 2010-08-06 US US13/386,550 patent/US8697719B2/en not_active Expired - Fee Related
- 2010-08-06 NZ NZ597920A patent/NZ597920A/en not_active IP Right Cessation
- 2010-08-06 CN CN201080044044.4A patent/CN102639531B/zh not_active Expired - Fee Related
- 2010-08-06 IN IN968DEN2012 patent/IN2012DN00968A/en unknown
- 2010-08-06 WO PCT/GB2010/051310 patent/WO2011015882A2/en active Application Filing
-
2014
- 2014-04-07 US US14/246,291 patent/US9181268B2/en active Active
-
2015
- 2015-08-05 JP JP2015155158A patent/JP2015214574A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015214574A (ja) | 2015-12-03 |
| US9181268B2 (en) | 2015-11-10 |
| AU2010280497B2 (en) | 2015-10-22 |
| US20120149725A1 (en) | 2012-06-14 |
| CN102639531B (zh) | 2016-01-20 |
| EP2462140A2 (en) | 2012-06-13 |
| JP5822831B2 (ja) | 2015-11-24 |
| JP2013501041A (ja) | 2013-01-10 |
| US8697719B2 (en) | 2014-04-15 |
| CN102639531A (zh) | 2012-08-15 |
| CA2768553C (en) | 2016-08-02 |
| NZ624602A (en) | 2015-11-27 |
| WO2011015882A2 (en) | 2011-02-10 |
| AU2010280497A1 (en) | 2012-02-23 |
| NZ597920A (en) | 2014-05-30 |
| US20150051241A9 (en) | 2015-02-19 |
| US20140249175A1 (en) | 2014-09-04 |
| CA2931876A1 (en) | 2011-02-10 |
| WO2011015882A3 (en) | 2011-09-01 |
| AU2010280497A8 (en) | 2012-03-08 |
| CA2768553A1 (en) | 2011-02-10 |
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